This review provides a critical and translational analysis of GSH-responsive nanomedicine, highlighting chemical strategies such as disulfide/diselenide linkages, transition metal systems, and GSH-activated prodrugs
GHK-Cu Copper Peptides: The "Holy Grail" of anti-aging
Edited by Professor Boris Zhivotovsky Rights and permissions Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made
Collectively, these recent contributions argue that future GSH-centric redox sensing and nanomedical approaches should (i) incorporate organelle targeting (especially mitochondria) to exploit subcellular redox heterogeneity, (ii) embed analyte-responsive activation into both therapeutic and imaging components, (iii) combine biochemical sensing with optical or thermal engineering for spatiotemporal control, and (iv) favor clinically translatable carriers (e.g., PLGA) for delivery
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