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A plethora of PASC clinical symptoms and related metabolic impairments indicate involvement of different pathobiological mechanisms such as (i) virus-induced hypoxia/Warburg effect, (ii) iron (Fe)-redox dysregulation (FeRD), (iii) m- Dys and altered bioenergetics, (iv) oxidative stress (OxS) and cellular damage, (v) immuno-pathogenesis and hyperinflammation, (vi) autoimmunity, (vii) dysbiosis, (viii) re-activation of latent pathogens, (ix) persistent viral reservoirs, and (x) viral-hijacked host cellular factors 22,27,137,138

426,427 In a low pH environment, fusogenic peptides undergo pH-dependent conformational changes to form -helices, which insert into the endosomal membrane, causing instability and decomposition of the membrane structure

Nat Rev Endocrinol 16 , 165176 (2020)

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