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contraindications include pregnancy, breastfeeding, certain kidney or liver conditions, and some medications

Nat Rev Neurol 22 , 209225 (2026)

GIPR agonism could exert beneficial metabolic effects by enhancing glucose-stimulated insulin secretion, increasing postprandial adipose tissue blood flow and triglyceride storage, and by attenuating weight loss-induced bone loss by decreasing bone resorption and increasing osteoblast activity