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Moreover, some studies have shown that the ChaC1 protein is significantly upregulated in various adverse conditions, such as diabetes, viral infection and atherosclerosis, providing cells with the amino acid nutrients they need under stressful situations but reducing GSH levels

Amino Acids 31:2733 Nieminen ML, Tuomisto L, Solatunturi E, Eriksson L, Paasonen MK (1988) Taurine in the osmoregulation of the Brattleboro rat

High endothelial venules as potential gateways for therapeutics

G3 (Bethesda) 9(11):36113621 Garca-Ruiz C, Morales A, Ballesta A, Rods J, Kaplowitz N, Fernndez-Checa JC (1994) Effect of chronic ethanol feeding on glutathione and functional integrity of mitochondria in periportal and perivenous rat hepatocytes