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Marlboro's largest cigarette manufacturing plant is located in Richmond, Virginia

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[150] The birth of this evidence-based and systematic approach has resulted in the reinforcement of tobacco taxes and the implementation of smoke-free laws in 128 countries that led to the decrease of smoking prevalence in developing nations

This compensatory behavior can result in higher cumulative exposure to nicotine, tar, and other toxic substances, which are significant contributors to respiratory and cardiovascular diseases