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It has been found that mitochondrial fission occurs at the contact points between the OMM and endoplasmic reticulum (ER) tubules, which are determined prior to the recruitment of DRP1 ( In vitro experiments have confirmed that knockdown of INF2 and Spire1C lead to elongated mitochondria and reduced binding of DRP1 to mitochondria (Manor et al., 2015)

Moreover, as eczema is a complex disease, it is likely that multiple factors interact to influence its onset and progression