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In vivo studies Experimental work Animals were maintained under specific-pathogen-free conditions and in compliance with the Northern Ireland Department of Health (under PPL 2874 and 2960) regulations with approval from the QUB Animal Welfare and Ethical Review Body

These results showed how glutathione has antioxidative and antiatherogenic properties and can lead to the remission of atherosclerosis [167]

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The present review thus focuses on the role of GPX4 in the myeloid lineage, describing how increase in GPX4 expression can impact on myeloid cell homeostasis and transformation and whether GPX4 inhibition could represent an attractive strategy to treat AML patients