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Clin Chim Acta 312:227229 Erden-Inal M, Sunal E, Kanbak G (2002) Age-related changes in the glutathione redox system

This form of programmed cell death has been identified in various pathologies, including cardiovascular diseases, cancers, kidney diseases, and brain disorders [237, 238]

Within this framework, our observation of reduced thalamic GSH during the interictal phase may be regarded as a candidate neurochemical correlate of these chronic, between-attack thalamic changes, possibly reflecting cumulative oxidative burden in a region chronically exposed to trigeminovascular input over years of recurrent attacks

Furthermore, LDL receptors become dysfunctional, increasing serum LDL-C, while inhibition of HDL-C concentration in the blood causes undesirable changes in lipid metabolism, producing hypercholesterolemia (Yousef et al