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Juul shut down its Facebook and Instagram accounts in November under regulatory pressure, but the net effect has been to make nicotine cool and socially acceptable to use for a new generation, decades after the last Marlboro man withered away

However, a more recent study has described impaired endothelial function even after a single nicotine-free ENDS session that was also accompanied by increased inflammatory mediators (i.e., serum CRP, plasma HMGB1) and oxidative stress [117]

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