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These include: Diacetyl a food additive used to deepen e-cigarette flavours that can also damage small passageways in the lungs Formaldehyde a toxic chemical that can cause lung disease and contribute to heart disease Acrolein a chemical more commonly used as a weed killer that can damage the lungs UK regulations require producers to provide ingredient information and do not permit certain compounds such as formaldehyde, acrolein and acetaldehyde in e-cigarettes or e-cigarette liquids sold in the UK

The prematurely activated immune system also reinforces selective pressure on tumor cells, further shaping the tumor microenvironment

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