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The classical pathway induced by TS is MAPK, which through multiple factors, mainly ERK1/2, can direct the signal to the nucleus to promote AP-1 phosphorylation, promoting their binding to cognate regulatory elements in cell promoters [115,116,117]

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What remains is a strong but more concentrated halal cluster centred on semiconductors (NVIDIA, Broadcom, ASML, Qualcomm), large-cap pharma (Eli Lilly, Novo Nordisk, Roche, Novartis, J&J, AstraZeneca, GSK), consumer staples (Procter & Gamble), payments infrastructure (Visa, Mastercard), industrial software (Adobe, Salesforce, SAP), and select energy and materials names (ExxonMobil, Chevron, Linde, BHP, Rio Tinto)