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Biological activity of the endocannabinoid system Once in the body, 9 -THC and CBD exert their effects via the endocannabinoid system (ECS).The identification of the specific binding sites for 9 -THC in the brain [45], complemented by the cloning of the cannabinoid receptor 1 (CB1), that led to the development of the concept of a cannabinoid receptor system given the binding of 9 -THC to CB1 as a partial agonist [46]

Nicotine spray: Nicotine is delivered by the nose or mouth through sprays

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As well as changes affecting the size of tanks and strength of nicotine-containing liquids, e-cigarette manufacturers will have to decide whether to apply for them to be regulated as either a consumer product or a medicinal one, with different marketing restrictions on each