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As shown in hyper-pneumonia sensitivity, generally similar to SARS-CoV-2 infection, the APC capacity and functioning are reduced in the airways, which attenuates the marshal of adaptive immunity and stimulation of uncontrolled cytokine storm and fibrotic responses

The perishing of the wicked in God's presence also points to the eschatological hope of a new creation where sin and evil are no more (Revelation 21:8)

In KS, a mutation in the FERMT1 gene results in loss of function, leading to keratinocyte detachment, duplication of the lamina densa, and multiple cleavage planes at different levels of the dermoepidermal junction, beginning at birth.5,7 From the first years of life all 4 patients presented skin fragility that subsequently diminished, leaving patients with cutaneous atrophy and poikiloderma predominantly in photo-exposed areas