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Cytisinicline is a naturally-occurring plant-based alkaloid that binds selectively to nicotinic receptors in the brain that regulate nicotine dependence, alleviating the urge to smoke and reducing the severity of nicotine withdrawal symptoms

We argue that much of this tension arises from a conceptual conflation between two distinct phases of the disease process: susceptibility to infection and progression to severe illness after infection has been established

Piper ME, Piasecki TM, Federman EB, Bolt DM, Smith SS, Fiore MC, et al

The discrepancy is due to the fact marijuana remains an illegal schedule I drug according to federal law