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Furthermore, the effect of LA (50mg/kg or 100mg/kg) on healthy animals was evaluated in the preliminary experiment, and no changes of renal morphology and function were found in the healthy mice after oral medications of LA (shown in Supplementary Figure 1)

The obvious culprits are running and biking, but those arent the only activities that suddenly spike in volume

BV suppresses COX-2 transcription, reducing the generation of inflammatory prostaglandins (Hegazi et al., 2013)

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