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Sex had a moderating effect on the meta-analysis outcome and is reasonable since it was known that the male-to-female ratio was 4:1 for ASD 4

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Indications: Guanethidine is no longer available in the USA due to lack of availability, but is available in the UK (wikipedia) Was used for severe cases of hypertension, either alone or as an adjunct drug Contraindications: Guanethidine can cause a hypertensive crisis in patients with pheochromocytoma due to the release of catecholamines (tyramine like action)

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We aim to provide a comprehensive research initiative: GLUTASCAN for AD patients as well as to detect MCI in early stages based on our previous study [4]

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