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The global epidemiology of NAFLD and NASH in patients with type 2 diabetes: a systematic review and meta-analysis

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During ferroptosis, heme oxygenase 1 (Hmox1) is up-regulated with increased free iron release from cardiomyocytes, and then left ventricular remodeling would be triggered, causing severely impaired function of left ventricular in MI patients (Song et al., 2021) (Figure 1)

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Generating sufficient safety evidence would require large-scale clinical trials involving thousands of participants

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