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Symptoms of a nicotine overdose include: nausea headache heavy, labored breathing loss of appetite shallow breathing slow heart rate diarrhea Drug interactions Some prescription medications can interact with nicotine

Furthermore, little is known about how vaping affects the use of and dependence on tobacco cigarettes, nor is much known regarding total nicotine use and dependence

Products like ZYN have not been validated and approved by the FDA to help people quit using tobacco products. Crystal Leatherman of the Washington Retail Association expressed concerns with adding an increased tax on a product that is not taxed at such a high level in neighboring states

route for 28 consecutive days once daily, without exposure to nicotine