Seizures Nicotex 2 Sugar Free Classic Fresh Mint Chewing Gum should be used with caution if you have a history of seizures (fits) as this medicine may increase your risk of a seizure attack
Cardiovascular diseases We identified 37 studies (59 observations) 177,207,208,215,225,236,252,262,274,275,276,277,278,279,280,281,282,283,284,285,286,287,288,289,290,291,292,293,294,295,296,297,298,299,300,301,302 quantifying the relationship between SHS exposure and IHD and 20 studies (26 observations) 176,207,208,225,236,252,262,278,296,297,303,304,305,306,307,308,309,310,311,312 assessing the relationship between SHS and stroke (Table 2 and Supplementary Tables 4 and 5)
Additive effects of nicotine and high-fat diet on hepatic steatosis in male mice
I have not found any issue so far