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In the cosmetics industry, scale matters not only for manufacturing efficiency but also for supply chain reliability

Integron-like elements were surveyed using the IntegronFinder tool (Galaxy Version 2.0.2 + galaxy1) available in the Galaxy platform (Nron et al., 2022)

The main challenge is potential irritation at very high concentrations (above 20%), but formulations between 10-20% are generally safe and effective

Furthermore, the excessive accumulation of ROS not only disrupts the process of melanin synthesis, but also destabilises, synthesises and disrupts the circulation of lipids in melanocytes, resulting in damage to the mitochondrial electron transport chain and increased ROS production, creating a vicious cycle and destroying melanocytes [19]