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Additionally, niacin has been noted to increase fasting blood glucose by inducing insulin resistance in some cases

Like many therapeutic peptides, it may require daily (or near-daily) administration, as in the previously referenced mouse and rabbit studies.12 17 Moreover, as a preventive or a drug for managing chronic health conditions, treatment ought to be ongoing and may involve periodic breaks in dosing (cycling), which is also common with many therapeutic peptides

The mechanism that likely drives this gap is the combination of GIP and glucagon receptor activation working together