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The South Dakota Medicine journal writes of twin and family studies that have shown that there are several genes that cause an individual to become more susceptible to being addicted to nicotine. The genes in question determine how many receptors the brain produces to metabolize the nicotine in an inhalation

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However, this applied to a study with a puffing regime, while a study with 90 min ad libitum use of e-cigarettes reported varying nicotine curve shapes with an overall slower increase over time