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The concept was first introduced in 1979, and numerous trials, usually combining nicotine fading with other behavioral modifications, were conducted throughout the 1980s

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Key toxicants include carbon monoxide (CO) and hydrogen cyanide (HCN), both posing life-threatening risks

At the end of baseline evaluation, subjects in group 1 were asked to assume caffeine 100 mg administered orally (galenic preparation solved in 40 ml of water), a dosage that is equivalent to that of an express coffee