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Additionally, bacteria can develop resistance mechanisms such as modifying membrane charge, producing proteases, altering metabolism, or forming biofilms, which can reduce LL-37s effectiveness

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The disorder is caused by a defective or abnormally altered gene that causes one of the proteins responsible for the initial arrest of bleeding (called von Willebrand factor) to be low or not function properly

Also, they activate enzyme reactions of corresponding proteins, forming holoenzymes that participate in the majority of cellular processes