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doi: 10.3389/fragi.2022.931331 85

These compartments operate as integrated interfaces for stress perception, modulation, and transduction, in which edaphic changes act as primary causal drivers shaping plant physiological and molecular responses

Although the effect of mB12/LDFA and BH4 on methylation and glutathione metabolism have been examined in the open-label studies, these changes have not been compared to controls who received a placebo in order to account for the natural variation in the changes in these pathways

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