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However, severe reactions such as difficulty breathing, facial swelling, and anaphylaxis occur in rare cases, indicating a serious allergic reaction that requires immediate medical attention

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Intervention with diosmin and trolox (a water-soluble vitamin E that can be used to scavenge ROS) in rats administered complete freunds adjuvant (CFA) reduced the levels of various peroxidation products and production of various MMPs and elevated the Nrf2 activity, inflammatory response, and cartilage destruction in CFA-administered rats (293)

It also minimizes the activity of free radicals in the body, preventing the activation of melanin-producing enzymes