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In Drosophila , enhancing BNIP3-mediated mitophagy in the nervous system improves mitochondrial homeostasis, thereby extending lifespan, and improving muscle and gut homeostasis

A recent systematic review and meta-analysis of 21 randomized, placebo-controlled trials examining the effect of B-vitamin supplementation found the supplementation decreased homocysteine concentrations and improved measures global cognitive function but had no effect on individual measures of executive function, information processing speed, or episodic memory (89)

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