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Int Arch Allergy Appl Immunol

In any case, the structure of the Co II -bound NiCo riboswitch reveals four Co II binding sites that likely nucleate formation of a four-way junction stabilized by a network of contacts that may explain how cooperative binding of Co II ions to adjacent sites might be achieved (Figure 22D)

Although the mechanism by which oxidizing agents is distinct from ionizing radiation, conditions like severe sepsis and septic shock also create an oxidation-rich environment that leads to the depletion of natural cellular antioxidants (such as glutathione) and contributes to cellular injury and death