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Retrieved March 14, 2018, from Australian Government Department of Health (2014)

Nicotine has significant biologic activity and adversely affects several physiological systems including the cardiovascular, respiratory, immunological and reproductive systems, and can also compromise lung and kidney function [41]

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Otherwise, your perfectly rolled cigarette is just going to burn weird, taste awful, or go out faster than a cheap birthday candle.The standard go-to is Brightleaf tobaccomild, slightly sweet, and commonly used in commercial cigarettes