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Various inflammation-related regulatory factors (such as NOD-like receptor thermal protein domain-associated protein 3 (NLRP3), Toll-like receptor 4 (TLR4), high mobility group box 1 (HMGB1)) are involved in the regulation of heat stress-related SIRS [25]: After heat stimulation in the rat model, NLRP3 combines with pro-caspase-1 and the CARD-containing apoptosis-associated speck-like protein (ASC) to form the NLRP3 inflammasome complex

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Moreover, we show that both ShD14 and divergent clade ShHTLs, but not conserved and intermediate clade ShHTLs, can interact with the putative downstream signaling component ShMAX2 in the presence of the synthetic strigolactone, rac -GR24