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Vitamin B12 injection frequency depends on the cause and severity of deficiency

Antithrombin III inhibits thrombin and other enzymes in the coagulation process

So people at greatest risk for deficiency include those with low stomach acid (e.g., older adults and people on proton pump inhibitors or antacids) or low IF production (known as pernicious anemia), people on medications that interfere with B12 absorption (such as metformin), people who have had gastric surgery, those with GI conditions that impair nutrient absorption (like celiac or Crohn's disease), and people on vegan and vegetarian diets

I needed to correct my injection site to be more lateral on the thigh to do it in the right muscle