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Efficacy and safety evaluations demonstrated that this nanomedicine could overcome glioma drug resistance and reduce side effects [36] (Fig

Glutathione is formed from three amino acids, glutamine, which is found in food protein sources such as meats, glycine, which is found in high enough concentrations in all foods and cysteine, which is the rate limiting factor in the formation of glutathione

This modification enhances NNTs affinity for its substrate NADP+, promoting NADPH synthesis, maintaining ironsulfur cluster homeostasis, lowering intracellular ferrous iron levels and lipid peroxidation, and thereby protecting tumor cells from ferroptosis (118)