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These results are supported by a recent randomized placebo controlled trial, which demonstrated that a 6-week sulforaphane intervention (30 mg/day) safely improved depressive symptoms, as measured by the Hamilton Rating Scale for Depression, in 66 participants with a history of a cardiac procedure and presence of mild to moderate depression (Ghazizadeh-Hashemi et al., 2021)

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In this section, we present rough estimates of the number of people in each stage of the Alzheimer's disease continuum from no cognitive impairment to severe dementia (see Table 3A), based on a very recently available populationbased study that included Alzheimer's disease biomarkers

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doi: 10.1016/j.ejps.2012.03.010 209 HassanAASayyahSG

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