Figure 7: Chronic liver disease (steatosis, steatohepatitis, and cirrhosis) is linked to excess inflammatory proteins and fat deposits, which disrupt energy production and metabolism
As mitochondria produce energy, they naturally generate free radicals known as Reactive Oxygen Species (ROS), such as superoxide and hydrogen peroxide
Available evidence suggests a role for voltage-dependent anion channel (VDAC), located in the OMM, and adenine nucleotide translocase (ANT) across the IMM ( 2 + -induced swelling and MPT, although at a higher threshold, which has been interpreted as evidence against a role for ANT in MPT (Sileikyte et al., 2014)
[DOI] [PubMed] [Google Scholar] 217.Welsch D.J., Creely D.P., Hauser S.D., Mathis K.J., Krivi G.G., Isakson P.C