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PMID: 20228417 Cantin AM, Hubbard RC, Crystal RG

The lack of defined genetic drivers in most patients limits the immediate applicability of precision gene-silencing approaches, necessitating a shift towards targeting convergent pathological pathways and developing biomarkers for patient stratification

2.10.1 Limitation of in-vitro model Despite their value in mechanistic research, in vitro models present several critical limitations that constrain their translational applicability (Slanzi et al., 2020)