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In an uncontrolled clinical trial in 23 women with rosacea, use of a topical 0.05% retinaldehyde cream once daily for six months led to modest improvement in rosacea-related facial redness and telangiectasia in 75% of participants

Diarrhea Reported by 20-30% of users, generally resolving as the body adapts to each new dose level

However, no standard strategy for the TME has been achieved at present, still having a long way to go before optimizing PDT in the TME

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