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However, the prospective Shanghai Osteoarthritis Cohort study showed that GLP-1RA users with KOA and diabetes exhibited a greater reduction in Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) total and pain score and a lower occurrence of knee surgery compared to controls

It is chemically a small-molecule, non-peptide compound rather than a true peptide, even though it is routinely grouped alongside peptides such as ipamorelin or CJC-1295 in bodybuilding content because it acts on the same GH/ghrelin pathway