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We suspect that this may be an underrecognized cause for metabolic acidosis in the ICU and we would agree with the suggestion that 5-oxoproline excess should be routinely considered in the differential diagnosis for a cause for a metabolic acidosis [17].

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Additional in vivo studies (diabetic and control rats) studied the effects of an evening primrose oil (EPO) supplement and ALA supplement on various lipid and hemostatic parameters

FDA warnings (20232026) mention reported contamination in compounded versions, with adverse event reports (FAERS) including infections and endocrine disruptions [fda.gov]