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For instance, activating mutations in KRAS or BRAF markedly reduce the efficacy of EGFR inhibitors, illustrating the limitations of current approaches in addressing the molecular complexity of CRC [4]

As a result of increased homocysteine concentrations, the breast cancer cell lines MCF-7 and MDA-MB-231 revealed epigenetic modulations of BRACA1 and RASS-F1 (167)

DlugoszANowakPD'AmatoMMohammadian KermaniGNystromJAbdurahmanSet al

Thus, although downregulation of a GPCR invariably adds to the overall desensitization of a GPCR response, most GPCRs can undergo extensive desensitization (particularly, following acute agonist addition) without any downregulation being detectable