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This mechanism remains less well characterized than the two previous ones and requires further independent validation

For in vitro experiments, embryonic rat cardiomyocytes (H9c2 cells) exposed to hypoxia-reoxygenation (HR) showed a time-dependent increase in gp91 phox (a marker for ROS production by NADPH oxidases), caspase-3 (a key mediator of apoptosis) expression, and a decrease in the glutathione redox ratio

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Une mta-analyse de 9 essais contrls randomiss confirme que les effets sur la composition corporelle sont statistiquement significatifs mais ncessitent d'tre associs une alimentation adapte et l'exercice physique pour obtenir des rsultats optimaux