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351 A global lactylome profiling of cancerous and adjacent tissues from 40 patients with gastrointestinal cancer also identified 11698 Kla sites, highlighting its role in cancer processes, including epigenetic rewiring, metabolic perturbations, and genome instability

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Their bioavailability is less affected by changes in liver function or blood flow but is more dependent on the extent of absorption from the gut The relationship F = 1 - E gives rise to an important, non-linear amplification effect that explains the dramatic nature of some drug-drug interactions for high-extraction drugs