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The GDH2 complex is not inhibited by GTP which allows astrocyte GDH2 to continue to function under conditions of intense excitatory neurotransmission allowing these cells to handle the increased loads of the neurotransmitter glutamate

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Acknowledgements We sincerely thank Ya-Hui Tsai, PhD, research specialist in the Division of Pediatric Surgery, Department of Surgery, Far-Eastern Memorial Hospital for editing the figures in the manuscript

In breast cancer, GPx2 is commonly overexpressed in the mammary carcinomas of mouse models of breast cancer induced by carcinogens, which is consistent with its up-regulation in human breast cancer [19]