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Increased lipid peroxidation in sera of ALS patients: a potential biomarker of disease burden

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Despite that mitochondria are exposed to the generation of oxidant species, the existence of an efficient antioxidant defense system, of which mGSH is a critical component, prevents or repairs oxidative damage generated during normal aerobic metabolism ( MITOCHONDRIAL ROS GENERATION AND DEFENSE Reactive oxygen species can be generated in several intracellular sites, including cytosol, peroxisomes, plasma membrane, and ER

Pathway analysis further identified cholesterol metabolism ( INSIG1 , FDFT1 , SREBF1 , LDLR and so on) as being modulated by both C1-27 and GSTO1 knockdown