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(C) 2+ -dependent EV biogenesis and cargo sorting, enriching pro-metastatic proteins (e.g., MMP2/MMP9) and altering miRNA profiles (upregulate oncogenic miR-155/-21/-210 and suppress tumor-suppressive miR-126/-200c)

Furthermore, proinflammatory mediators, such as ROS, NO, and Cox-2, play a key role in the pathogenesis of many acute inflammatory diseases [17]

In our standard procedure for PELD, only the protruding part of the NP and part of the NP around the broken AF were removed, with most of the NP remaining intact in the intervertebral disc

The Japanese Orthopaedic Association (JOA) scale was used to evaluate the severity and improvement of low back pain