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Clinical and postmortem studies consistently demonstrate reduced BDNF expression and diminished neurogenic capacity in individuals with depression, while effective antidepressant treatments, including SSRIs, SNRIs, and electroconvulsive therapy, restore neurogenesis and promote neuronal maturation

44 Research has found STAT3 to be an active factor in signal transduction and transcription

Dual-energy X-ray absorptiometry (DEXA) scans showed increases in lean tissue in both groups, yet the vitamin group gained more arm lean mass and had a larger rise in skeletal muscle mass index , meaning more women crossed above the diagnostic cutoff for low muscle mass

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