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When joint aches do occur temporally alongside B12 therapy, they are more likely coincidental or related to other factors rather than a direct pharmacological effect of the vitamin itself

It also enables your doctor to evaluate your vitamin B12 levels to prevent overdosing

Proton-pump inhibitors (e.g., omeprazole, esomeprazole, and lansoprazole), used to treat Zollinger-Ellison syndrome and gastroesophageal reflux disease (GERD), markedly decrease stomach acid secretion required for the release of vitamin B 12 from food but not from supplements

PRP injections for knee arthritis are one non-surgical option that may help selected patients, particularly where symptoms are persistent but joint replacement is not yet the right step