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The pharmacokinetic barrier has recently been overcome with the synthesis of the orally active, blood-brain barrierpermeable analog N-hexanoic-tyrosine-isoleucine-(6) aminohexanoic amide (dihexa)

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A sleeve gastrectomy removes 7580% of the stomach, reducing capacity from around 1,0001,500 ml to approximately 80150 ml immediately after surgery

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