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2F), a diterpenoid chemical ingredient of Salviae miltiorrhizae Radix et Rhizoma , is primarily used to treat cardiovascular and cerebrovascular diseases like atherosclerosis and hypertension due to its anti-inflammatory and endothelial regulatory effects [65,66,67]
doi: 10.1016/j.biopha.2020.110439 271 Sa-nguanmooPTanajakPKerdphooSJaiwongkamTWangXLiangGet al
doi: 10.1080/10715760500072172
In chronic pain and depression, chronic exposure to stress is a common factor that may produce long-lasting changes (i.e., maladaptive neuroplasticity) in highly sensitive brain areas such as the prefrontal cortex and the hippocampus and in their functional connections, which may underlie the cognitive and behavioral impairments accompanying these conditions (Teffer and Semendeferi, 2012
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