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as a result, renal ammonia production contributes to systemic hyperammonemia [49]

5.2.5 Future directions: targeting cell-type specific ferroptosis programs Emerging single-cell and spatial transcriptomic analyses have revealed that ferroptosis susceptibility varies significantly among different joint-resident cells in OA

Therefore, this may reduce the flow of TCA and ultimately impair energy supply

Although considered a safe drug [139], larger studies are urgently needed to assess the potential benefit of vitamin B12, either alone or in conjunction with other therapeutic agents, in preventing or reversing MS and improving the quality of features of patients with MS [140]