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Another BBB-crossing molecule with HGF-like activity, BB3, was employed in pre-clinical models of stroke, showing good functional improvements (Chaparro et al., 2015)

There was a significant decrease in serum concentrations of coagulation factors including PAI-1 and the cell adhesion molecules VCAM-1 and ICAM-1, while there was an increase in IL-13 and IL-8 between T1 and T2 (Extended Data Fig